Ketamine vs. Spravato for Depression

In an nutshell: Ketamine = esketamine (Spravato) + arketamine. Clinically, they differ in route, cost, and purpose. Here’s how I sort out which one makes sense for a given patient.

Ketamine vs SSRIs for Depression: A Doctor’s Comparison

As a doctor who has prescribed thousands of SSRIs over the past 15 years, this is my honest comparison of ketamine and SSRIs based on mechanisms of action, efficacy, side effects, and practical considerations.